Pharmaceutical Biochemistry (BBK4005) - VDU Biochemijos ir biotechnologijų katedra
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Pharmaceutical Biochemistry (BBK4005)

Course code

Course group

Volume in ECTS credits

Course hours

BBK 4005

C

3

80

Course type (compulsory or optional)

Optional

Course level (study cycle)

Bachelor

Semester the course is delivered

Autumn

Study form (face-to-face or distant)

Face-to-face

Course title in Lithuanian

Farmacinė Biochemija

Course title in English

PHARMACEUTICAL BIOCHEMISTRY

Short course annotation in Lithuanian

Tai tarpdisciplininis kursas jungiantis chemiją, biochemiją ir farmacinę chemiją. Kurse pateikiama informacija apie pagrindinių biocheminių molekulių savybes, jų  metabolizmą bei kai kurias medžiagų apykaitos sutrikimų  sukeliamas ligas. Apžvelgsime vaistų patekimo į organizmą, poveikį medžiagų apykaitai, bei  metabolizmo/biotransformacijos kelius gyvuose organizmuose. Ši informacija siejama su  naujų terapinių būdų, susijusių su ląstelės metabolizmo modifikavimu,  kūrimu

Short course annotation in English

In an interdisciplinary course combining the knowledge in biochemistry and pharmaceutical chemistry to the necessity of drugs. This course presents a wide variety of information of drug action, drug transport, drug delivery, and targeting. All of this information is central to understanding that the development of new pharmaceuticals is dependent on a molecular-level understanding of biological processes and mechanisms of drug action.

Prerequisites for entering the course

Inorganic and Bioinorganic chemistry, Organic chemistry, Biochemistry I and II

Course aim

The aim of course to introduce basic knowledge about the action of pharmaceutical agents and disease treatment   together with  molecular understanding of events.

Content (topics)

 1. Metabolism disorders and diseases. Drugs and xenobiotics. Drugs interaction with biological systems.
 2. Overview of drugs metabolism in the body.
 3. Metabolism and bioactivity. Factors affecting drugs metabolism.
 4. Cholesterol biosynthesis and metabolism and the action of cholesterol levellowering drugs.
 5. Physiological functions of glucocorticoids and their relation to pharmacological actions.
 6. Disorders of Carbohydrate Metabolism. Diabetes Mellitus.
 7. Disorders of purine metabolism. Podagra.
 8. Neurodegenerative disorder. Parkinson Alzheimer’s diseases.
 9. Histamine. histamine biosynthesis. Histamine antagonists.
 10. Nonsteroidal anti-inflammatory drugs. Mechanism of action and metabolism.

Practical work (contents):The course includes 5 practical works: 1) Determination of blood glucose concentration; 2) Enzymatic determination of total serum cholesterol; 3) Determination of serum low-density lipoprotein in blood serum; 4) Qualitative organic tests of ketone bodies. Determination of ketone bodies in urine; 5) Determination of concentration of uric acid in blood.

Distribution of workload for students (contact and independent work hours)

Lectures – 30 hours, laboratory work– 15 hours, mid-term and final examination – 6 hours individual work – 29 hours.

Structure of cumulative score and value of its constituent parts

Final assessment sums the assessments of written final examination (50%), written mid-term examination (25%) and assessment of laboratory works (25%).

Recommended reference materials

No.

 

Publication year

Authors of publication and title

Publishing house

Number of copies in

University library

Self-study rooms

Other libraries

Basic materials

1.

2003

A.Praškevičius, L.Ivanovienė, N.Stasiūnienė, J.Burneckienė, H.Rodovičius, L.Lukoševičius, D.Kondrotas. Biochemija

 

Printed KMU, Kaunas

22

1

 

2.

2008

Kadziauskas J. Biochemija

VU leidykla

70

1

 

Supplementary materials

1.

2006

Devlin, T.M., Textbook of  Biochemistry with Clinical Correlations, 6th edition,

John Wiley and.
Sons, Inc.

 

2.

2006

R.K. Murray, D.K. Granner, P.A. Mayes and V.W. Rodwell, "Harper’s Illustrated Biochemistry" Eds., 27th Edition

The McGraw-Hill

Companies, Inc., New York, NY.

 

Course programme designed by

Doc.dr. Zita Naučienė, Department of Biochemistry and Biotechnologies, Faculty of Natural Sciences

Additional information