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Cell Biology (BBK4001)

Course code

Course group

Volume in ECTS credits

Course hours

BBK4001

C

6

160

Course type (compulsory or optional)

Compulsory

Course level (study cycle)

Bachelor

Semester the course is delivered

Autumn

Study form (face-to-face or distant)

Face-to-face

Course title in Lithuanian

LĄSTELĖS BIOLOGIJA

Course title in English

CELL BIOLOGY

Short course annotation in Lithuanian

Ląstelės biologijos kursas suteikia bendrą supratimą apie ląstelių struktūrą ir funkcijas, organeles ir kitus ląstelės komponentus, jų funkcijas, sąveiką su savo mikroaplinka, įskaitant kaimynines ląsteles, tarpląstelinį užpildą, tirpius mediatorius. Supažindinama su ląstelės ciklu, jo reguliacija, vėžinių ląstelių ypatumais, apoptoze ir nekroze. Laboratoriniai darbai supažindina studentus su šiuolaikiniais ląstelių tyrimo metodais, įgyjama patirties vykdant klasikinius ląstelės biologijos eksperimentus.

Short course annotation in English  

The cell biology course provides a basic understanding of the structure and function of cellular organelles and components, the functional interaction of the cell with its microenvironment, including neighboring cells, the extracellular matrix and the soluble mediators. Introduction to the cell cycle, its regulation is presented, features of cancer cells, basic knowledge on apoptosis and necrosis. Classes are centered on discussion oriented lectures to encourage critical thinking and emphasize the significance of research as a tool to achieve knowledge. The laboratory part exposes students to an overview of modern cell-related techniques and hands on experience to classical cell biology experiments.

Prerequisites for entering the course

Basic Biology and General Biochemistry

Course aim

The aim of this course is to cover fundamenal aspects of the structure and function of cells and their organelles, to provide basic knowledge on cell cycle, apoptosis, features of cancer cells. Also modern cell biology problems and discoveries will be discussed

Content (topics)

 1. The cell theory. Composition of cytoplasm
 2. Structure and functions of plasmic membrane. Transport of substances into the cell
 3. Organisation of cytoskeleton. Cell movement
 4. Endoplasmic reticulum. Protein targeting. Molecular chaperones. Ubiquitine and 26S proteosomes
 5. Golgi complex. Lysosomes
 6. Nucleus. DNA organization levels
 7. Mitochondrial function and autonomy. Peroxisomes
 8. Pecularities of the plant cell
 9. Intercellular contacts and cell adhesion. Intercellular matrix
 10. Cell cycle. Cell division. Meyosys
 11. Intercellular signal transduction
 12. Apoptosis and necrosis
 13. Properties of cancer cell
 14. Biology of aging
 15. Methods in Cell biology

Practical work (contents):

  1. Properties of Cell membranes;
  2. Biochemical composition of cell: Carbohydrates;
  3. Biochemical composition of cell: DNA;
  4. Biochemical composition of cell: Proteins;
  5. Peroxidation of lipids;
  6. Estimation of cell viability;
  7. Photosynthesis in chloroplasts;
  8. Cell fractionation;
  9. Cell fraction marker enzymes;
  10. Staining of mitochondria using fluorescent dye MitoTracker.

Distribution of workload for students (contact and independent work hours)

Lectures – 45 h, practical work (laboratory practice) – 30 h, individual work – 78 h, assessment of knowledge (control work, mid-term examination, final examination) – 7 h

Structure of cumulative score and value of its constituent parts

Final assessment sums the assessments of written final examination (50%), written mid-term examination (20%), assessment of laboratory works (30%).

Recommended reference materials

No.

 

Publication year

Authors of publication and title

Publishing house

Number of copies in

University library

Self-study rooms

Other libraries 

Basic materials

1.

2004

Mildažienė, V., Jarmalaitė, S., Daugelavičius, R. Ląstelės biologija

Kaunas: VDU leidykla

 

70

3

 

2.

2005

Karp, G. Cell and Molecular Biology.

Academic Press

3

1

 

Supplementary materials

1.

2001

Lodish, H., Baltimore, D., Berk, A., Zipursky, S.L., Matsudaira, P., Darnell J. (2000). Molecular Cell Biology

Cambridge University Press

 

2.

2002

Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P. Molecular Biology of the Cell

 

 

3.

2012

http://www.biophysics.org/btol/bioenerg.html

Internet

 

4.

2012

http://members.tripod.com/mitoart/database/index/i-bioenr.htm

Internet

 

5

2012

http://web.chem.ucsb.edu/~molvisual/ABLE/membrane_biochem/index.html

Internet

 

Course programme designed by

Prof.dr.Rimantas Daugelavičius, Department of Biochemistry and Biotechnologies, Faculty of Natural Sciences

Additional information